During cadaveric dissection of a male in his mid-50s, gynecomastia and evidence of liver disease were noted. The cause of death was listed as cardiac arrest. Tissue samples were taken for histopathological analysis from the liver and breast and were stained with H&E to distinguish gynecomastia from malignancy and pseudogynecomastia. Results confirm gynecomastia and cirrhosis of the liver. Gynecomastia can result from cirrhosis due to the disruption of estrogen metabolism leading to the accumulation of free estrogen and resulting in the development of mammary ducts and other structures. The links between these two conditions are discussed, including treatment.
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